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TEMPE, Ariz., Sept. 7, 2004 – Atomic force microscopes (AFMs) allow scientists to peer at the nano world. Up until now, however, AFMs have largely focused on academic research. Tempe, Ariz.-based Molecular Imaging Corp. is working to expand that focus and open doors to other research markets, including nanotechnology and nano-level life sciences.
The firm’s desire to delve into markets such as life sciences has been accelerated in the last decade by the development of the Arizona Biodesign Institute at Arizona State University (ASU), the school that gave birth to nearby Molecular Imaging (MI) in 1993.
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“This will be the best place in the world for this [bioscience] type of activity. Period,” said Stuart Lindsay, an ASU physics researcher who co-founded the firm.
“Unless there’s an earthquake and MI and ASU fall into a hole in the ground, what you see now is just the starting point.”
Lindsay’s recently published research on new MI AFM systems demonstrated a technique that allows scientists to monitor the effects of potential drugs on an ever-smaller scale, a process which could speed up drug-discovery efforts.
Lindsay was one among a half-dozen scientists who worked on the study published in the proceedings of the National Academy of Sciences. The PicoTREC AFM system used in the study was selected in July by R&D Magazine as one of the 100 most technologically significant products of the year.
The nanotech applications of Molecular Imaging’s products include testing properties of organic and inorganic nanotubes and single-molecule electronic switches, according to Daphna Yaniv, MI’s former marketing director.
AFMs are a type of scanning probe microscope (SPM) where a probe scans a surface and detects features as tiny as a tenth of a nanometer. The scanned information is translated into a visual image on a computer screen.
“I like to compare it to an old-style phonograph needle,” said Vance Nau, MI’s president and CEO. “You’re skimming across a surface and you’re sensing that surface.”
Transmission electron microscopy produces higher-resolution nano-scale images, but it can only view objects in a vacuum, Nau said.
“AFM is the only way to get that [nano] level of resolution under ambient conditions,” said Nau. Thus, researchers can run tests at various temperatures and in various environments to simulate real-world conditions.
AFMs “have applications in almost every nanotechnology field,” according to a report by Business Communications Co. (BBC), a Norwalk, Conn.-based technology analyst. BCC forecasts the AFM market, already at $200 million a year, will grow at about 22.4-percent annually through 2008.
MI has grown even faster: 25 and 35 percent, respectively, in each of the last two years, according to Nau. He attributes the growth to the introduction of the PicoPlus, the first “second-generation AFM.”
“The focus with the PicoPlus is ‘one system does it all,'” he said. “You would have to buy three or four AFMs [from other vendors] to match PicoPlus.” And AFMs, as a Fortune article recently noted, aren’t cheap, ranging in price from $100,000 for research systems to $2 million for systems designed for industrial use.
Lindsay and Tianwei Jing, Lindsay’s former research associate at ASU, founded MI in 1993. Today, Lindsay is the firm’s vice president of technology, and Jing is senior vice president of engineering. Lindsay still heads the Lindsay Lab at ASU’s physics department, as well.
The Lindsay Lab built its own microscopes until Digital Instruments introduced a commercial AFM in 1987. Although the microscopes were more reliable, Lindsay said researchers “had to work like hell to modify [Digital Instrument’s AFMs] to get them to do what we wanted them to do.”
When Jing came to ASU in 1992, he built an AFM that worked so well that other scientists asked him to build them one.
“His version of the microscope was so nice that it finally clicked that maybe we should be selling these things,” Lindsay said. Thus, MI was born with the licensing of the patent on Jing’s design from ASU. The company now has 40 patents in its inventory.
“Outside of [competitors] Veeco and Seiko, we’re probably the most prolific [in patents],” Nau said. “Our focus is innovation, developing new tools that might open up new markets and niches.”
Company
Molecular Imaging Corp.
Headquarters
4666 S. Ash Ave.
Tempe, Ariz. 85282
History
ASU Professors Stuart Lindsay and Tianwei Jing founded MI in 1993. The company manufactures AFM) and SPM systems designed for imaging in fluid or air, and appropriate for nanotechnology research applications in multiple areas. MI also develops software and data management tools.
In 1994, Gatan International acquired MI. Gatan and MI were then purchased by Roper Industries in 1996. On April 8, 2002, MI once again became an independent company as a result of a management-led buyout completed by Peacock and Hislop.
Industries potentially served
- biomedical/life sciences
- materials
Selected small tech-related products and services
- PicoTREC Topography & RECognition AFM Imaging
- PicoPlus SPM: a second-generation AFM with modular scanner and multi-user capabilities
- Pico LE SPM: available at a more affordable price, without full-featured functionality of other product offerings
Employees
20 to 49
Management
- Vance Nau, president and chief executive officer
- Stuart Lindsay, vice president of technology
- Tianwei Jing, vice president of research and development
- Sam Buffington, chief financial officer
- Barbara Rice, marketing communications and public relations
Financials
Company revenues in 2003 leaped into the $5-$10-million range, up from the $1-$5-million range in 2002.
Selected strategic partners and customers
Selected competitors
Barriers to market
Like other manufacturers of industrial imaging equipment, MI executives are constantly working on ways of simplifying their products and make them part of a laboratory or research organization’s everyday routine. Cost is another barrier to expanding their market.
Relevant patents
Vibrating tip conducting probe microscope
Magnetically oscillated probe microscope for operation in liquids
Contact info
Research by Gretchen McNeely