The M-110EH-30 is designed to produce small batches of nano-suspensions and -emulsions. (Photo: Microfluidics)

November 21, 2007 — Microfluidics’ latest Microfluidizer high-shear processor, the M-110EH-30, now incorporates new capabilities and features into the original system architecture. Promising reliable and efficient operation at up to 30,000 psi process pressure, the M-110EH-30 enables the production of nano-suspensions and nano-emulsions, as well as liposomal encapsulation and cell disruption with the least number of passes.

The M-110EH-30 is designed to produce small batches for clinical trials and for other pilot runs. It comes standard with a diamond interaction chamber and provides an average flow rate (with water) of 330 ml/min at 30,000 psi process pressure and can easily handle batch sizes of up to several gallons. A second, replacement ceramic interaction chamber, also included at no additional cost, can increases the average flow rate (with water) to 450 ml/minute when processing materials that require lower pressures of 20,000 to 25,000 psi. This allows for more efficient processing of a wider range of pharmaceutical formulations, fine chemicals, and biological material ranging from simple oil-in-water emulsions to highly immiscible solids-in-liquid suspensions.

All results from the M-110EH-30 machine are guaranteed to be scaleable to Microfluidics’ broad line of M-700 pilot and production machines.

Using fixed geometry interaction chamber technology, the M-110EH-30 can generate shear rates within the product stream that Microfluidics says are orders of magnitude greater than any other fluid processing or mixing equipment on the market. Shear rate imparts the required energy directly to the product stream, safely disrupting bacteria cells and reducing particles and droplets to nanoparticles.