Isolators play an important role in reducing contamination through exposure to airborne particles and human contact. Developers of enclosed environment equipment must not only focus on the cleanliness of the internal atmosphere, but also keep in mind how the design will affect user experience and safety.

Compiled by Jason Andrukaitis

Built-to-order isolation equipment

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Clean Rooms International has been providing built-to-order isolation equipment since 1982 and has developed the expertise necessary to provide flexible solutions for customers. The company develops creative products for adding clean air, extracting contaminants, isolating major problem areas, and more. An isolator can mean many different things, so Clean Rooms International provides customization of isolation equipment. Customers produce the requirements, and the company will develop an approach that is unique to each business. For product questions, estimates, or to place an order call 616-452-8700 or e-mail [email protected]

Clean Rooms International

Grand Rapids, MI

Stent coating isolator

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EnGuard Systems, an established leader in the design and manufacture of isolators, has developed a stent coating isolator for use as an integral part of the safe and efficient development of coronary artery stents. In this custom application, the company’s ability to understand the process resulted in ergonomic integration of the process, the equipment, and the isolator. The stent coating isolator employs multiple safety devices and a process logic controller for the complex management of hazardous gases and interlock systems. EnGuard’s practical approach to isolation technology was developed from many years of hands-on pharmaceutical manufacturing experience. In addition to this application, the firm provides isolators for totally contained processing of potent compounds, aseptic applications, and parenteral products. EnGuard’s portable enclosures provide maximum interaction with the process while protecting the product and the personnel. EnGuard Systems provides complete isolator service from initial concept to validation support.

EnGuard Systems
Indianapolis, IN

Controlled atmosphere gloveboxes

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Precise™ controlled atmosphere gloveboxes offer high-end construction and features at economical prices. These gloveboxes maintain a leak-tight, controlled condition environment for applications such as organometallic chemistry, alternative energy cells, and hydrophilic chemicals. The boxes are capable of maintaining low levels of oxygen (as low as 5 ppm) or moisture (as low as 50 ppm). Features include a one-piece molded, medium-density polyethylene shell, which is chemical-resistant and easy to clean; a viewing window of 1/4-inch thick laminated safety glass; and six manual valves for purging, filling, and drying train connections. Space-saving inner and outer transfer chamber doors that pivot upward are counterbalanced and equipped with quick-latches and pressure relief valve. The generous 13 ft3 interior of the main chamber meets Class 1 atmosphere conditions for leak rate per ISO 10648-2 test methods. The transfer chamber is 11 inches long and also features a pressure gauge with readings from 0 to


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