Aphios awarded SBIR grant for nano treatment of marijuana addiction

October 28, 2008: Aphios Corporation has received a Phase I Small Business Innovative Research (SBIR) grant from the National Institute on Drug Abuse (NIDA) to develop an improved oral formulation of Δ9-THC for marijuana addiction and unmet medical needs.

According to Dr. Trevor P. Castor, the grant’s principal investigator, “In addition to helping marijuana addicts overcome their addiction, the nanotech formulation of Δ9-THC will have applicability in several other chronic diseases, such as cancer pain, AIDS wasting, emesis, cachexia, obesity, smoking cessation, schizophrenia, multiple sclerosis and Parkinson’s disease.”

Innovative and novel dosage formulations are needed to improve the effectiveness and/or minimize the abuse potential of therapeutic agents for drug abuse/dependence. Δ9-THC has been shown to alleviate marijuana withdrawal symptoms and has potential for treating marijuana dependence.

Aphios plans to utilize its patented SFS-CXP manufacturing technology platform to manufacture pharmaceutical-grade Δ9-THC with a >99% purity following cGMP. Aphios will then utilize patented polymer nanospheres nanotechnology platform (SFS-PNS) to encapsulate Δ9-THC in biodegradable polymer nanospheres. Nanoencapsulation will protect Δ9-THC transport to the stomach and enhance its passage across the stomach lining of the gut. Nanoencapsulation will also slow the release of Δ9-THC, controlling the amount of drug in the bloodstream and reducing the frequency of drug administration during the day. Nanoencapsulation in biodegradable polymer nanospheres will thus improve Δ9-THC’s stability, prolong circulation time and enhance bioavailability. Alternatively, the formulation will be utilized to deliver Δ9-THC from a subcutaneously implanted depot.

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