Automatic high-content image analysis simplifies cell research

October 6, 2008: New software from Carl Zeiss automatically extracts biologically relevant data from micrographs by combining high-resolution fluorescence imaging and complex image analysis. Developed with the high content screening specialist, Cellomics, the AxioVision ASSAYbuilder module inherits 15 years of experience in the field of high-content analysis (HCA) to offer a reliable method of high content analysis and screening.

ASSAYbuilder supports the examination of processes in cells, between cells or in small organisms and will be especially useful in studies such as apoptosis, cytotoxicity, molecule localization and translocation, cell differentiation and proliferation, GFP expression, and GPCR signal pathways. For example, users can analyze the position of the cytoskeleton or determine the proportion of living and dead cells in a sample. Furthermore, it allows the characterization of cell cultures, the identification of new cellular starting points for the development of future medication, and the identification of lead substances in small or medium screenings in pharmaceutical research.

The software module is sufficiently powerful to cope with even highly sophisticated requirements, such as subpopulation analyses.

ASSAYbuilder is compatible with almost all inverted or upright ZEISS imaging systems and stereomicroscopes from Carl Zeiss and other AxioVision software modules. Automated hardware, such as motorized microscope stages, permits the setup of a screening station that can also be designed as a living cell screening station by using incubation components.

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