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Mar. 15, 2006 – Arrowhead Research Corp. (NASDAQ: ARWR) announced that the U.S. Food and Drug Administration has approved the investigational new drug (IND) application submitted by its majority-owned subsidiary Insert Therapeutics Inc. Under the IND, Insert will conduct a Phase I study for IT-101, its first anti-cancer therapeutic, at the City of Hope in Duarte, California.

IT-101 is a nanotechnology-based therapeutic that combines Insert’s Cyclosert technology and the anti-cancer compound camptothecin. Cyclosert is a linear cyclodextrin polymer that was invented at Caltech in the lab of Mark Davis, a professor in chemical engineering and founder of Insert.

The Phase I trial will be an open-label, dose-escalation clinical trial of IT-101 in patients with all types of cancer. The trial is expected to enroll between 24 and 48 patients and has been designed to determine safety and tolerability of IT-101.

Mar. 15, 2006 – Polychromix Inc., a developer of material analysis, chemical sensing and spectroscopy solutions, announced the launch of the Phazir product, a handheld near infrared digital transform spectrometer analyzer.

The product combines a digital transform spectrometer engine, a Polychromix MobiLight lightsource, reflectance probe, rechargeable batteries, integrated computer and LCD display and software into a unit that can be used din field applications. It is the latest version of Polychromix’s line of spectroscopy products.

Mar. 14, 2006 – JMAR Technologies Inc. (NASDAQ: JMAR), a developer of laser technology for nanoscale imaging, analysis and fabrication, has signed an agreement with Portaqua, a Virginia-based company that is introducing a new portable water system into the bottling market, for its BioSentry water quality monitoring system.

Under the agreement, BioSentry will be offered as an optional feature of the Portaqua system. BioSentry is a contamination warning system for waterborne microorganisms. Whereas current water monitoring depends on batch sampling, BioSentry uses laser-based technology to provide continuous, online, real-time monitoring for harmful bacteria and protozoa. It is targeted towards a number of applications across multiple industries, including municipal drinking water utilities, the beverage industry, and homeland security.

Mar. 14, 2006 – Lumera Corp. (NASDAQ: LMRA), a nanotechnology company, announced the promotion of Tim Londergan and Raluca Dinu to head its bioscience and electro-optics business units, respectively.

Londergan will serve as the new director of the bioscience business unit. In 2000, he became Lumera’s first employee as a senior chemist. Over the past five years he has been a key driver in the marketing of Lumera technology and bio-related products to both research and commercial institutions, according to a news release.

Dinu becomes director of the electro-optics business unit. She joined Lumera in 2000 as a physicist and has been integral in developing and handling fabrication and testing of Lumera’s patented polymer modulators.

Along with the director level promotions, two individuals, HannWen Guan, and Dan Jin, were named to associate director positions.

Mar. 14, 2006 – The National Center for Manufacturing Sciences (NCMS) in Ann Arbor, Mich., has compiled the results of nearly 600 U.S. industry executives who participated in its nanomanufacturing industry survey — a cross-industry survey of nanotechnology commercialization trends and concerns sponsored by the National Science Foundation (NSF).

“The survey … shows the increased significance of nanotechnology to both traditional and emerging fields in the last five years,” said Mike Roco, the NSF’s senior advisor for nanotechnology, in a prepared statement.

An abstract of the survey, which addresses strategic issues related to the commercialization of nanotechnology, is available online at the NCMS Web site. Small Times provided logistical support for the survey.

Mar. 14, 2006 – Sensor System Solutions Inc. (OTC.BB: SSYO), a manufacturer of MEMS sensors, intelligent sensor interface electronics and intelligent embedded control systems, announced it has signed an agreement with X-Labs Global, a technology advisory and consulting firm based in Los Angeles.

The agreement will allow the entities to establish the framework to explore ways to exploit mutually beneficial products and services to expand business activities into India. X-Labs Global will use its market knowledge, domain insights, global network and business relationships to introduce Sensor System Solutions’ products and services to emerging markets. X-Labs will also seek to develop opportunities and identify potential strategic partnerships or joint ventures to complement the company’s technology and its capabilities.

Mar. 13, 2006 – Acacia Research Corp. (NASDAQ: CBMX, ACTG) announced that its CombiMatrix group’s subsidiary, CombiMatrix Molecular Diagnostics, and Array Genomics Inc. of France will co-develop, market, and sell a new series of comparative genomic hybridization microarray products and services.

The initial products will be manufactured in the U.S. by Combimatrix and distributed in Europe by Array Genomics, a privately held company.

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Mar. 10, 2006 – The Safer Nano 2006 symposium held in Beaverton, Ore., on Monday and Tuesday looked at best practices and regulatory activities being developed to ensure “Nano for a Safer World.”

The Oregon locale was a logical choice, a state whose green credentials are impeccable as the home of environmental activism, the nation’s first bottle bill, and state laws requiring reforestation and salmon restoration projects.

“This is a unique meeting in the country,” said Skip Rung, executive director of Oregon Nanoscience and Microtechnologies Institute (ONAMI), which sponsored the event along with FEI Co., Oregon Health & Science University’s OGI School of Science and Engineering, and Kennedy/Jenks Consultants.

The latest state environmental initiative is ONAMI’s Safer Nanomaterials and Nanomanufacturing Initiative (SNNI), led by University of Oregon’s Jim Hutchison. Oregon academics are aiming to get a head-start on developing a niche for their nanotech funding.

Hutchison and Peter Mirau and Rajesh Naik, of the Air Force Research Lab in Ohio, said their goals are to enhance integration of SNNI activities and identify and explore areas of mutual interest between the two efforts.

“One of the things the Air Force does is put things into the air,” Mirau noted. Nanocomposites and interfaces can help reduce weights of materials, though researchers are still in the fundamental research stage.

Hutchison’s green approach is to test properties of various nanoparticles, then take that information and feed it back into product design repeatedly, while watching out for waste, toxicity and other environmental hazards.

Barbara Karn, currently at the Wilson International Center for Scholars during a sabbatical from her position at the U.S. Environmental Protection Agency, and Sean Murdock, executive director of the NanoBusiness Alliance, described problems and principles of green nano.

“Today we are attempting to look at risks proactively,” said Karn, a chemist and marine ecologist. She advised workers in nanotech to consider risk, both real and perceived; governance of risk; effects of nanotech research on the environment; and ways to prevent harm.

Governance of risk is a regulatory matter, she said, requiring careful definitions, measurements and even names for the new nanomaterials. Are they chemicals, or products? Who does the regulating? What is new? What standards should be adopted? Are they harmful or beneficial?

Questions that need to be addressed include, how do you characterize risk? Under the 30-year old Toxic Substances Control Act (TSCA), the EPA tracks more than 75,000 industrial chemicals, Karn said, although not all are toxic.

Karn is concentrating on a green nanotechnology framework, looking for products that don’t hurt the environment and ones that can help it in areas like remediation, energy conservation and waste reduction.

The EPA began to devise a plan for dealing with existing or future problems associated with nanotech six years ago. They have looked at green energy and manufacturing, toxicology, life cycle aspects, and biological actions, such as accumulation and availability.

EPA screens pre-manufacturing notices required under the TSCA, which has exemptions for very small volumes of materials. This applies to nanomaterials. “The EPA is trying to get around this, so they can look at nanomaterials, too,” she said.

Regulators want to establish a voluntary program for corporations that don’t fall under TSCA. “This can help EPA conduct a risk assessment and develop a permanent and mandatory program,” Karn said. “Nobody knows enough to do this yet.”

The alternative isn’t pleasant. Some alarmists are suggesting banning nanomaterials, others are asking for labeling regulations.

Work on environment, health and safety (EHS) issues has been done at the federal level, chiefly during a Congressional subcommittee hearing on the topic, but most state level nanotech projects aren’t singling out these issues for special attention.

Chief among EHS problems that need to be solved on the local research and industrial level are hundreds of unanswered questions relating to new nanoparticles and materials, a point made by speaker after speaker during the symposium. A second issue for the field is that two different approaches are being proposed, Rung said.

He noted that some critics advocate new laws and regulations, because they say nanoparticles are different from other materials. However, he and others believe current regulations are flexible enough to cover nanotechnology impacts.

Concentrating on safety and health provides opportunities to lower materials used in various processes, the NanoBusiness Alliance’ Sean Murdock said.

“Using nanomaterials to impart new properties to materials is not new, but the ability to control those properties by controlling the composition, size and spacing of nanoparticles is new.” He noted that the EPA is the most likely nanotech regulator, though OSHA rules protect workers and FDA protects consumers.

“This meeting is a telling example of how things are different” today from the past, he said, allaying fears that nanoparticles could be the next asbestos or genetically modified organisms. “The apparatus is already in place, although we lack resources and data” to devise specific regulations.

Mar. 10, 2006 — The Project on Emerging Nanotechnologies at the Woodrow Wilson International Center for Scholars today launched a nanotechnology consumer products inventory. The inventory is accessible at www.nanotechproject.org/consumerproducts. It contains information on 212 products that the center believes use some form of nanotechnology.

“With this inventory, we also are learning that this technology is already being incorporated into our daily lives,” said David Rejeski, director of the Project on Emerging Nanotechnologies, in a prepared statement. A news release said the inventory furthers the Project on Emerging Nanotechnology’s mission to encourage discussion about nanotechnology’s benefits and its promise, as well as its safety and environmental impacts.

The project began compiling products and materials containing nanotechnology from around the globe for inclusion in the consumer inventory in 2005, according to a news release. The release said that inclusion in the list is mostly based on information posted online by manufacturers.

The effort found that most of the products were in the health and fitness category, ranging from face creams to hockey sticks to clothing, such as stain-resistant shirts, pants and neckties. It also found that that most of the products were in the U.S. However, the project noted that research for the list was based on English language Web sites.

The center will formally launch the products inventory today at 2 p.m. at the Woodrow Wilson International Center for Scholars in Washington, D.C.

FEI sells tool to BASF


March 10, 2006

Mar. 10, 2006 – FEI Co. of Hillsboro, Ore., announced that BASF has ordered one of its top-of-the-line DualBeam systems, the Strata 400. The system features a focused ion beam for nanoscale milling and deposition, and a scanning electron microscope for ultra-high resolution imaging below 100nm.

The Strata will be utilized in BASF laboratories, along with previously installed FEI Tecnai transmission electron microscopes for a wide range of R&D projects. These projects include, among others, the study and establishment of processes for the reliable detection, monitoring and characterization of nanoparticles as part of the European Union’s NanoSafe research project, the development of nanostructured coatings aimed at preventing algae and mollusks from colonizing on ship hulls, and the development of products that can reduce the emission of CO2 gases from power generating stations.