Tag Archives: Small Times Magazine

Dec. 1, 2005 — FEI Co. of Hillsboro, Ore., announced it has introduced its next-generation Vitrobot, an automated vitrification device for plunge-freezing of aqueous samples.

The system maintains the cryo-fixation process at constant and user-definable physical and mechanical conditions, delivering reproducible sample freezing and high throughput.

The technique of cryo fixation and imaging of aqueous samples at cryo temperatures in a transmission electron microscope is used in nanobio research and by the chemical and pharmaceutical industries for studying colloidal solutions of polymers, pigments and other nanoparticles.

Dec. 1, 2005 — Agilent Technologies Inc. (NYSE:A), the Hewlett-Packard spinout that recently reoriented itself to focus on test and measurement applications, moved into the atomic force microscope market this week when it announced the acquisition of Molecular Imaging Corp. of Tempe, Ariz.

The acquisition is intended to support Agilent’s broad goal of addressing test and measurement markets for both electronics and life sciences, according to Bob Burns, general manager of Agilent’s Nano Measurements Division. In addition, it is intended to take advantage of business and technology synergies between the two organizations.

Agilent’s global sales staff is expected to substantially increase the exposure of the Molecular Imaging AFM product line. In turn, said Vance Nau, president and CEO of Molecular Imaging, the acquisition will help his staff members focus on their core responsibilities.

Molecular Imaging’s chief product line is the PicoPlus family of modular, high-resolution AFMs, which are used for imaging in fluids as well as ambient and controlled environmental and temperature conditions. Customers are currently researchers in the areas of drug discovery, life science, electrochemistry, materials science and polymer science.

On the technical side, Burns said he and Nau shared “a vision…to take this technology and evolve it to the next level.” In particular, the executives explained, that means working to simultaneously improve performance and ease-of-use.

“Right now scanning probe microscopes are still very much something that needs to be operated by a specialist,” said Burns. He said the company intended to improve the device’s speed as well as add functionality that would make imaging less reliant on the interpretive abilities of the user.

“To broaden the customer base, you need to greatly simplify it,” said Nau, who said if the device were easier to use, then a technician could operate it rather than a Ph.D. scientist. Other long-range plans include automating devices for specific applications in manufacturing and other areas.

Burns said Agilent will keep the Molecular Imaging group — which numbers roughly 40 people — in Tempe because the company has strong ties with Arizona State University. Nau said all Molecular Imaging employees were offered positions with Agilent and that “virtually 100 percent” accepted them. Molecular Imaging was founded in 1993 by Stuart Lindsay and Tianwei Jing of Arizona State University.

– David Forman

Nov. 30, 2005 — Adnavance Technologies Inc., a Vancouver, British Columbia nanobiotechnology company, announced that it has completed a Series A round of financing totaling $3.85 million.

The company is developing product applications that use the electrical conductivity properties of both DNA and novel metallic forms of DNA for healthcare and nanotechnology applications.

The round was led by the Working Opportunity Fund, with additional participation from BC Medical Innovations Fund, Canadian Medical Discoveries Fund and the Business Development Bank of Canada.

The proceeds will be used to advance the company’s core M-DNA technology for a number of commercial applications, with a primary focus on the development of ultra high sensitivity biosensors, molecular detection devices used to improve medical diagnosis and predict disease outcome. The company’s technology is designed to enable the detection of a variety of infectious diseases, both viral and bacterial, in less than five minutes. It also is working on other applications.

The company has also secured substantial funding from The National Research Council’s Industrial Research Assistance Program and from The Natural Sciences and Engineering Research Council of Canada to support its research and development programs.

Nov. 30, 2005 — NanoDynamics Inc. of Buffalo, N.Y., and ALD NanoSolutions of Broomfield, Colo., announced a partnership to develop coatings for electronics applications.

NanoDynamics says that — using ALD’s atomic layer deposition technology — it has developed a new manufacturing approach to creating uniform, nanometer thick coatings that encapsulate powders along with other elements, enabling them to retain inherent thermal and conductive properties while eliminating reactivity and functionality issues.

Nov. 30, 2005 — Boston Micromachines Corp., a provider of MEMS-based deformable mirror products for adaptive optics systems, announced that it has been selected by NASA for a Phase 2 contract.

NASA’s Small Business Innovation Research Program (SBIR) awarded Boston Micromachines an approximately $600,000 contract to develop a deformable mirror suitable for space-based operation in systems for high-resolution imaging.

The company says the mirror will be fabricated through a combination of MEMS fabrication techniques using single crystal silicon for all structural components. This mirror is intended to eventually operate in space as part of a future observatory mission for the detection of planets in other solar systems.

In a separate project already underway, Boston Micromachines is providing a high-resolution MEMS deformable mirror for a NASA-sponsored space exploration project led by Boston University. The project’s mission objective is to obtain a direct image of an extrasolar giant planet. Its telescope, which uses Boston Micromachines’ MEMS mirror for wavefront control, is slated to be launched from White Sands, N.M., aboard a NASA sounding rocket in early 2007.

Nov. 30, 2005 – The Institute of Electrical and Electronics Engineers (IEEE) announced it has begun work on a new standard, “Standard Methods for the Characterization of Carbon Nanotubes Used as Additives in Bulk Materials”. Known as IEEE P1690, the standard is expected to be the first to define methods for testing carbon nanotube additives and how to report the resulting performance data.

“This standard should aid the acceptance and diffusion of carbon nanotube technology,” said Krishna Kalyanasundaram, chair of the Carbon Nanotube Characterization Working Group, in a prepared statement. “It will help nanotube producers characterize purity, dispersion and other properties and also give end users confidence in evaluating carbon nanotubes from different sources. IEEE P1690 will apply to nanotubes independent of how they were fabricated.”

The IEEE said the standard will recommend instruments and procedures for validating nanotube purity, concentration, dispersion rate, agglomeration and other properties. In the area of purity, for instance, it will address the presence of non-carbon substances, such as metal catalysts and carbon-like molecules. It will give material suppliers a structure for providing data and offer guidance on proper levels for dispersion and agglomeration, which affect nanotube dispersion shelf life.

“The P1690 Working Group has undertaken the task of developing a standard that will serve as the model for future nanoscale materials-related standards,” said Dan Gamota, chair of the IEEE Nanotechnology Council Standards Committee, in a prepared statement. “Krishna has the strong support of the IEEE Nanotechnology Council Standards Committee to lead this working group as it drafts one of the most critical standards along the nanotechnology value chain.”

November 28, 2005 – For the better part of a decade, the United States and India have been building closer economic ties. Now efforts to forge more scientific ties — including the lucrative field of nanotechnology — have leaped forward.

The two nations signed a long-anticipated agreement last month that cleared away the bureaucratic brush that had previously stymied research partnerships between the world’s largest democracies. Signed by Secretary of State Condoleezza Rice and Indian Science and Technology Minister Kapil Sibal, the pact settles long-standing disputes on how to share intellectual property rights as well as questions of taxation, import-export customs and similar issues.

The agreement does not create any cross-border collaborations themselves. It does, however, free academic, corporate and government scientists to strike what partnerships they can in basic research around space exploration, biotechnology, energy, nanotechnology and more.

State Department spokesmen said the deal allows more substantive collaborations that delve into potentially valuable discoveries. They added that and nanotech is certainly a high priority.

The United States and India have tried to foster research collaboration in some way or another since 1987. Until now, however, the sticking point had been how to share licensing revenues from any “co-inventions” that a collaboration might create. The October agreement gives each nation exclusive rights to license intellectual property in its own country, and promises to share licensing revenues in other countries using formulas to be negotiated on a per-case basis.

State Department officials say that both countries have wanted to wrap up a deal in recent years; once the IP provisions were settled, the rest quickly fell into place.

Speaking to reporters at the signing, Sibal said India is now “in mission mode” to develop nanotechnology, but stressed that the governments prefer that scientists develop specific areas of collaborative research themselves.

“They are already doing that at an individual level, at a project-to-project level, but under the umbrella of this agreement, the extent of collaboration will be far more diverse,” he said. “The depth of collaboration will be far more interactive.”

What happens next is not entirely clear, but Indian brainpower mixed with American venture capital and research sophistication could be a potent combination. Already, according to a survey of venture capitalists done by Deloitte & Touche last spring, 20 percent of U.S. VC firms plan to increase their investment abroad and list India as a top destination. Draper Fisher Jurvetson, a VC heavyweight in Silicon Valley, has plans to pour $200 million into Indian startups. Venture Intelligence India estimates that American VC firms put $397 million into Indian companies in second-quarter 2005 alone.

To be sure, most of those investments are going into call centers and other information technology-related businesses far removed from nanotech. Other concerns remain as well: Meyya Meyyappan, director of NASA’s Ames Research Center for Nanotechnology, lamented the tight security regulations that prevent sensitive government researchers like his staff from collaborating with foreigners. “We don’t even try to collaborate with people outside the country,” he said.

Yet even Meyyappan agreed that more commercially oriented work, especially in Corporate America, could benefit from such deals. “Nanotech is a totally unconstrained business,” he said. “They could do whatever they want to.”

“There is a lot of interest on both sides,” said Harvard University physicist Anita Goel, a trustee of the Nanotechnology Innovation and Research Foundation. Goel said she receives frequent invitations to work with Indian technology incubators or research efforts, plus inquiries from the Indian government on how they should train their scientists.

Many people want to recreate the success enjoyed by the IT industry in the last 10 years, where U.S.-based money and expertise paid for low-cost Indian skilled labor to manage large projects like reprogramming computer code for the Year 2000 bug. Since then a host of Indian IT companies have sprung up to work with U.S. corporations, stimulating Indian economic growth in the process.

The Indian government would welcome the opportunity to expand that relationship to basic sciences, and has poured money into its network of technical universities around the nation.

“They’re not making a passive effort, certainly,” Goel said.

Who might benefit from the agreement? One example is Arunava Majumdar, a mechanical engineering professor at the University of California, Berkeley and a native of India. He already exchanges annual visits with a counterpart at the Indian Institute of Technology (IIT) in Bombay, and hopes that closer ties will help researchers in both nations stay in contact with each other amid today’s tougher U.S. immigration policies.

“There are tremendous opportunities here … Just look at the quality of students,” he said. “It’s absolutely critical for us to keep in touch with the talent over there and in China.”

A graduate of IIT himself, Majumdar admits that India still lacks the sophisticated facilities necessary to do nanotech research. “The U.S. can help there. That’s a tremendous resource we have,” he said. Meanwhile, the United States can tap a large pool of scientists. “And not just graduate students — real, professional scientists,” he added, “who don’t often have the opportunity to flourish because of the poor facilities.”

Nov. 23, 2005 – Lux Research Inc., a research and advisory firm focusing on the business and economic impact of nanotechnology, announced that it has hired Mark Bunger as a senior analyst to further expand the firm’s west coast operations.

Bunger was most recently a principal analyst at Forrester Research, where he studied and advised clients in manufacturing industries including automotive and aerospace. Prior to that, he was an international engagement manager at European consultancy Icon Medialab, as well as the managing director of Icon Medialab’s U.S. office.

Nov. 23, 2005 — Cascade Microtech, a maker of tools for precise electrical measurements on small structures, announced it is expanding its capabilities in the semiconductor failure analysis market.

The company recently introduced the eVue digital imaging system, a new tool for sub-micron probing to ease the problems of failure analysis on rapidly shrinking geometries. On Tuesday, it announced that it has entered into a business and technology partnership with Credence Systems Corp. to further expand its failure analysis market penetration. The terms of the relationship were not disclosed.

“Credence’s leadership in complete offerings of proven 65nm debug and diagnostics equipment is strategic to Cascade’s launch of our failure analysis product line,” said John Pence, vice president of the engineering products division at Cascade, in a prepared statement.

Nov. 23, 2005 — iCurie Inc., a maker of thermal management products for computers and consumer electronics, named George Meyer as vice president of sales and marketing, and general manager for the Americas and Europe.

Meyer will be responsible for developing key customer relationships, managing the company’s product portfolio, and growing sales throughout the industry. Meyer was an executive at Thermacore International, a subsidiary of Modine Manufacturing, from 1977 to 2004.