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Sep. 21, 2005 – The National Cancer Institute (NCI), part of the National Institutes of Health, and the National Science Foundation (NSF) announced a collaboration that will establish integrative training environments for U.S. science and engineering doctoral students to focus on interdisciplinary nanoscience and technology research with applications to cancer. Through this partnership, $12.8 million in grants are being awarded to four institutions over the next five years.

All of the four selected projects, each of which will support approximately 30 students, are linked to regional cancer centers and the biomedical research community.

Grants were awarded to:

  • Integrative Nanoscience and Microsystems, University of New Mexico, Albuquerque, N.M. This program is a collaboration between the University of New Mexico’s Center for High Technology Materials within the School of Engineering, the College of Arts and Sciences, and the Cancer Research and Treatment Center. The collective goal is to prepare graduates to utilize nanoscale phenomena to create macroscopic functionality in biointerfaces, information nanotechnology, and complex functional materials. The principal investigator is Diana Huffaker.

  • NanoPharmaceutical Engineering and Science, Rutgers University, New Brunswick, N.J. This collaboration between Rutgers, the New Jersey Institute of Technology, and the University of Puerto Rico, will prepare trainees to develop nanoparticle-based biocompatible drug delivery systems. The principal investigator is Fernando Muzzio.

  • Nanomedical Science and Technology, Northeastern University, Boston, Mass. This project will establish a new interdisciplinary doctoral education program in Nanomedical Science and Technology. The program aims to educate scientists to apply nanotechnology to human health, with business, ethical and global perspectives. The project will also involve investigators from Dana-Farber Cancer Institute and the Massachusetts General Hospital. The principal investigator is Srinivas Sridhar.

  • Building Leadership for the Nanotechnology Workforce of Tomorrow, University of Washington, Seattle, Wash. This joint institute for nanotechnology involving University of Washington, Pacific Northwest National Laboratory, and Fred Hutchinson Cancer Research Center, will focus on new directions in bionanotechnology such as medical applications of nanoscale platforms; use of nanoscale tools to understand biological mechanisms underlying disease and to diagnose and treat disease; and combining expertise and techniques across physical science, biomedicine and engineering. The principal investigator is Marjorie Olmstead.

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Sep. 21, 2005 – Two large nanotech-related private financings were announced on Tuesday. Molecular Imprints, a maker of nanoimprint lithography tools, announced it had raised $17 million in the first closing of what it plans to be a $25 million Series C round. Kereos, a developer of cancer therapy and imaging products using targeted nanoparticles, announced it had raised a $19.5 million Series B financing.

Harris & Harris Group (Nasdaq:TINY), a publicly-traded venture capital firm that specializes in nanotechnology, MEMS and microsystems companies, participated in both the Molecular Imprints and Kereos rounds.

Other participants in the Molecular Imprints round included Dai Nippon Printing Company, Alloy Ventures, Motorola Ventures, Draper Fisher Jurvetson, Hakuto Co. Ltd., Asset Management Partners and other unnamed investors.

Molecular Imprints, based in Austin, Texas, builds nanoimprint tools for the semiconductor and electronics industries and has sold to chip and device makers in markets including semiconductor components, photonics, advanced packaging, data storage and MEMS/NEMS fabrication.

It previously raised a $30 million Series B round, half of which closed in December 2003 and half in April 2004. Initial funding was a $12 million Series A raised in two closings announced in 2002.

As for Kereos, new investors Prolog Ventures, Triathlon Medical Ventures and Charter Life Sciences led the round along with existing investor RiverVest Venture Partners. Existing investor Barnes-Jewish Hospital also participated. Additional new investors included Alafi Capital, Apjohn Ventures, Harris & Harris, Lux Capital, MB Venture Partners, Sigvion Capital and Vectis Life Science, as well as corporate investors Genentech and Royal Philips Electronics. The company raised an initial round of funding for an undisclosed amount in 2001.

Kereos, based in St. Louis, says the first two of its products are expected to enter clinical trials for solid tumors in 2006. It is working with Bristol-Myers Squibb Medical Imaging and Philips Medical Systems to develop its products for use in magnetic resonance imaging (MRI) and other types of imaging systems.

– David Forman

Sep. 21, 2005 – Advance Nanotech subsidiary Nano Electronics has licensed ferroelectric nanotube manufacturing technology from SAMCO of Japan and the University of Cambridge, UK. Nanotubes with ferroelectric properties were successfully fabricated by Samco Inc. of Japan in a collaboration with the university.

The technology is based on SAMCO’s “misted deposition” technique, which enables simultaneous fabrication on large numbers of microdevices. Ferroelectric nanotubes have applications in ink-jet printer heads, biochips and drug delivery systems.

Source: INSEAD InnovAsia

Sep. 20, 2005 – Applied Materials Inc., a Santa Clara, Calif., supplier of equipment and services to the semiconductor industry, announced a key advancement in nanoscale interface engineering with its new Applied Siconi Preclean process for fabricating leading-edge transistor contacts.

The Siconi Preclean is intended to replace conventional plasma-based sputter etch technology with a dry, chemical process that gently removes oxidized silicon under high vacuum. The company says the process prepares the wafer’s surface prior to the formation of the critical nickel silicide layer to create an interface with minimal damage, and that it reduces interface defects.

Sep. 20, 2005 — Lumera Corp. (NASDAQ:LMRA), a Bothell, Wash., nanotechnology company, announced that it has successfully shipped electro-optic modulators to multiple customers.

The company has received orders for electro-optic modulators from Raytheon, undisclosed defense contractors and government agencies during the past six months. Additionally, a semiconductor chip company ordered modulators to evaluate for board level and chip level optical interconnects.

Chief Executive Officer Tom Mino said in a prepared statement that it was an important milestone for the company and demonstrates its continuing evolution from a research company to a commercial product provider.

Lumera is using proprietary nanotechnology to develop materials addressing several markets. It is currently developing products for the telecommunications and biotech markets.

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Sep. 20, 2005 – Rahul Patwardhan says the biggest problem facing the development of nanotechnology in India today is neither equipment nor education nor public distrust.

Rather, says the president and chief executive of private-equity group IndiaCo, it’s money — in particular, the venture capital funds necessary to further grow companies that are already emerging as a result of nanotech research and development.

The fact that venture funding is the bottleneck is a telling sign of how successful India has been at encouraging innovation. “In the last year we’ve seen six or seven new companies created,” said Patwardhan. “Several of these companies already have products.…We were kind of expecting this to happen two years from now.”

Patwardhan and other experts cite a variety of trends to explain the recent growth. There’s globalization and outsourcing, of course, and a rash of companies looking to cut costs by moving research abroad. But that’s hardly the only force at work. India also benefits from a tradition of excellence in science and technology education, an English-speaking workforce, and western-style patent protection. The mixture of explicit government support and a cadre of expatriates returning home plants the seeds for decades of nano-powered progress.

Tim Harper, chief executive of nanotech consultancy Cientifica Ltd., says the benefit of outsourcing R&D to India is obvious. “Think of the costs of clinical trials,” he said, citing the figure of $1 million for a modest trial. “In India you can get the same work done for $100,000.”

This summer, Cientifica announced the launch of a joint venture with India’s YashNanotech to outsource nanotechnology R&D. Cientifica will serve as the public international face of the venture, while Yash will manage the Indian operation. In addition, says Harper, the venture will look to incubate its own technologies, specifically in health care and water treatment.

Cientifica is hardly alone. In June, Rutgers, The State University of New Jersey, and nanomaterials provider NEI Corp. established a cooperative research program in nanotechnology with the International Advanced Research Centre for Powder Metallurgy and New Materials in Hyderabad. The program is slated to explore ways to make metals harder, ceramics lighter and stronger, and protective coatings more durable.

And in July, Veeco Instruments opened a nanoscience center in Bangalore in partnership with the Jawaharlal Nehru Center (JNC) for Advanced Scientific Research. Veeco, which makes atomic force microscopes and other nanotechnology research equipment, sees not just a new R&D outsource location but also a burgeoning market for its products.

“Our equipment fits well into manufacturing as well as research,” explained John Bulman, Veeco’s executive vice president of worldwide sales and foreign operations. By putting cutting-edge equipment on the ground at JNC, Bulman said Veeco gets its wares in front of some of the best and brightest scientific minds of the country. As they and their students move out into industry and other research labs, so such thinking goes, they are more likely to bring along a preference for the tools with which they are familiar. Veeco contributed two AFMs and an optical profiler to the research center.

Not just smaller outfits see opportunities in India. Large corporations like Hewlett-Packard, Siemens and GE set up R&D facilities in India in recent years. GE, for its part, employs more than 2,200 people at its Bangalore R&D center, the largest of its global R&D centers outside the United States.

These and other organizations working in India are receiving strong support from the Indian government, especially from President A.P.J. Abdul Kalam. A physicist by training, Kalam delivered an April 2005 address at a meeting of nanotech researchers and development officials where he declared that he was convinced “that nano is the greatest building block” for health care and in structural materials, as well as in electronics and automation. He added that it will “become the platform for new cutting-edge technologies.”

He also called on the country’s technologists to develop a roadmap that would give its efforts a more specific shape and direction. If they did so, he promised, he would be willing “to give the needed thrust.”

Various groups have taken such advice to heart. Private equity group IndiaCo set up a non-profit subsidiary called IndiaNano two years ago in order to foster more nanotechnology research. It runs joint R&D programs between labs and commercial entities, functioning as a sort of domestic clearinghouse for nanotech commercialization efforts, and it organizes industry conferences.

Other groups have also begun organizing conferences. One, an international coalition of scientists and executives, is collaborating with the Associated Chambers of Commerce in Delhi to hold a conference for late this year or early next year to work on a nanotech roadmap.

“It’s an attempt to put all the leadership on the same platform,” said Sujeet Kumar, a senior scientist at Greatbatch Technologies, headquartered in upstate New York, who is working on the conference effort. “We are telling people in the U.S. who want to manufacture in India, or sell a product there, to come.”

If Kumar’s contacts are anything like Cientifica, NEI or Veeco, they may have multiple reasons. Veeco’s Bulman says the company stands to get a return on its investment far beyond just growing Asian sales. It also intends to get helpful information about using its tools for biotech and life sciences research, areas that Cientifica’s Harper says are expanding rapidly in India.

“If you go to a place like Johns Hopkins,” Bulman said, “there are AFMs in there but you don’t know too much about what’s going on.” By contrast, he says the spirit among researchers in India is more open and they are more willing to freely share with Veeco the results of their research and the techniques they might employ with the equipment. “It’s their way of showing the world that the U.S. doesn’t have a patent on brains.”

Sep. 19, 2005 – Applied Materials Inc. (NASDAQ:AMAT), a supplier of equipment and services to the global semiconductor industry, named Tom St. Dennis as senior vice president with responsibility for leading the company’s etch and front end products groups.

Most recently, St. Dennis was executive vice president of Novellus Systems Inc. St. Dennis was a senior executive at Applied Materials for seven years leading a number of key product groups before departing in 1999 to become CEO of Wind River Systems, a maker of embedded software.

Sep. 16, 2005 — Integrated Sensing Systems Inc. (ISSYS) in Ypsilanti, Mich., announced that it has been awarded $950,000 over a two-year period from the Michigan Technology Tri-Corridor Fund.

The award is dedicated to commercializing drug infusion products developed at ISSYS. Douglas Sparks, executive vice president, said in a prepared statement that the system ISSYS is developing can greatly reduce the number of errors seen during drug delivery by monitoring the drug dose, dose rate, volume, drug type and concentration. He said it can also detect occlusions or blockages in an IV line and sense air bubbles.

ISSYS, founded in 1995, develops advanced micromachining technologies for medical devices, microfluidic and scientific analytical sensing applications used in the development of drug infusion pumps and wireless, implantable sensing systems.

Sep. 16, 2005 — Nanometrics Inc. (Nasdaq:NANO), a supplier of integrated and standalone metrology equipment for the semiconductor industry, announced it has named Douglas McCutcheon, 57, to the position of executive vice president of finance and administration and chief financial officer, effective immediately.

McCutcheon, a veteran corporate finance executive with three decades of experience in the semiconductor equipment and related industries, will report to John Heaton, Nanometrics’ president and chief executive officer, and be responsible for managing Nanometrics’ financial operations.

Prior to joining Nanometrics, McCutcheon held the post of managing director, senior vice president and chief financial officer for Metron Technology, where he successfully managed the sale of Metron’s assets to Applied Materials. Before his post at Metron, McCutcheon was the senior vice president and chief financial officer for Asyst Technologies. McCutcheon has also held executive positions with Cadence Design Systems, Diasonics, Toshiba America Medical Systems, and Memorex Corp.

Sep. 16, 2005 — Dimatix, a Santa Clara, Calif., provider of commercial and industrial ink jet products, introduced its cartridge-based Dimatix Materials Printer (DMP) system, a complete, low-cost solution for high-precision jetting of functional fluids including nanoparticle-based metallic and organic materials on any type of surface, including plastic, metal sheets, silicon and paper.

The company says the “fill your own cartridge” concept together with a complete print system offers an extremely low cost of ownership. The turnkey system is intended to be a tool for corporations and research institutes to quickly develop and test processes and prototypes, as well as conduct low-volume manufacturing of a broad range of products from flexible circuits, RFID tags and displays to DNA arrays, optical lenses and wearable electronics.