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(November 23, 2010 – Marketwire) Marlow Industries, thermoelectrics manufacturer, recently expanded manufacturing operations in Ho Chi Minh City, Vietnam to expand capacity and provide low-cost, high-quality products to address the increasing needs of the market.

The site opened in August 2005, and now spans close to 5,000m2 in active factory/warehouse floor, with state-of-the-art equipment and an innovative approach to microelectronics assembly, and approximately 900 local employees. The facility offers stability, process capabilities, and production repeatability for markets such as gesture recognition electronics. The gesture recognition electronics market sparked the expansion of this facility in 2009-2010. Within the first four months of production, the Vietnam site obtained ISO 9001:2008 certification and produced almost four million units with zero return-rate.

Enforcing a "no-expat" policy, Marlow remains dedicated to developing local talent for the good of Vietnam, and providing high paying jobs. "The Vietnamese workforce has demonstrated a dedication to quality production with an eagerness to learn. This attitude gives management the confidence to continue investing in Vietnam and its employees," comments Kevin V. MacGibbon, president II-VI Vietnam.

Looking ahead, Marlow focuses on a $2.5 million site investment designed to support Marlow’s rapid market share increase in the commercial, telecom and automotive markets.

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(November 19, 2010 – Marketwire)Magnolia Solar Corporation (OTCBB: MGLT) welcomed Professor Zhong Lin (Z. L.) Wang, Distinguished Professor and Director, Center for Nanostructure Characterization at Georgia Tech, to its Technical Advisory Board (TAB). Professor Wang is a world-renowned expert in nanostructure growth and characterization of semiconductor materials and devices for energy harvesting technology.

Professor Wang has done pioneering work on Zinc Oxide (ZnO), Zinc Sulphide (ZnS) and related materials-based nanostructures, i.e. nanowires and nanorods growth technology, growth demonstration and pioneering work in its applications for energy harvesting technology and other optical sensor applications. His pioneering work in nanogenerators for energy harvesting has been recognized worldwide as one of the 10 most impacting technologies for the next 10-30 years by MIT Technology Review, New Scientist and other International publications. He is an inventor or co-inventor of many U.S. patents and has authored or co-authored more than 650 publications. Professor Wang is a Fellow of the American Physical Society (APS) and American Association of Advancement of Science (AAAS).

"Magnolia has several government-funded programs in process right now and we’ll use Professor Wang’s expertise in nanostructure materials, growth technology and innovative concepts to help us accelerate the development of the critical technologies required to produce Magnolia’s high efficiency third generation solar cells. Professor Wang will also be advising us on the development of our intellectual property portfolio and in the patent filing process. Programs that Magnolia will be spending considerable effort on during the remainder of this year and throughout 2011," noted Dr. Ashok K. Sood, president and CEO of Magnolia Solar Corporation.

Magnolia is developing solar cell technology to cover the ultraviolet, visible, and infrared part of the solar spectrum with a nano-based thin-film solar cell technology. For more information, please visit www.MagnoliaSolar.com.

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(November 19, 2010) — Optically active semiconductor nanopillar arrays now absorb sunlight better than ever, thanks to research carried out at Lawrence Berkeley National Laboratory and the University of California at Berkeley.[1] 

Nanopillar tune-up
"By tuning the shape and geometry of highly ordered nanopillar arrays of germanium or cadmium sulfide, we have been able to drastically enhance the optical absorption properties of our nanopillars," says Ali Javey, one of the researchers.

Javey and his group were the first to demonstrate a technique by which cadmium sulfide nanopillars can be mass-produced in large-scale flexible modules. In this latest work, they were able to produce nanopillars that absorb light as well or even better than commercial thin-film solar cells, using far less semiconductor material and without the need for antireflective coatings.

"To enhance the broadband optical absorption efficiency of our nanopillars, we used a novel dual-diameter structure that features a small (60 nm) diameter tip with minimal reflectance to allow more light in, and a large (130 nm) diameter base for maximal absorption to enable more light to be converted into electricity," Javey says. "This dual-diameter structure absorbed 99% of incident visible light, compared to the 85% absorption by our earlier nanopillars, which had the same diameter along their entire length."

Work has shown that 3D arrays of semiconductor nanopillars with well-defined diameter, length and pitch excel at trapping light while using less than half the semiconductor material required for thin-film solar cells made of compound semiconductors, such as cadmium telluride, and about 1% of the material used in solar cells made from bulk silicon. But until the work of Javey and his research group, fabricating such nanopillars was a complex and cumbersome procedure.

Alumina foil comes in handy
Javey and his colleagues fashioned their dual-diameter nanopillars from molds they made in 2.5-µm-thick alumina foil (see figure). A two-step anodization process was used to create an array of 1-µm-deep pores in the mold with dual diameters. Gold particles were then deposited into the pores to catalyze the growth of the semiconductor nanopillars.

The germanium nanopillars can be tuned to absorb infrared photons for highly sensitive detectors, and the cadmium sulfide/telluride nanopillars are ideal for solar cells. The fabrication technique is highly generic, Javey says; it could be used with numerous other semiconductor materials as well for specific applications. Recently, he and his group demonstrated that the cross-sectional portion of the nanopillar arrays can also be tuned to assume specific shapes–square, rectangle or circle–by changing the shape of the template.

REFERENCE:

1. Zhiyong Fan et al., Nano Letters, 10 (10), p. 3823 (2010).

Energy consumption is a growing problem, driving searches for solutions

by David Hwang, Lux Research

November 18, 2010 – Energy consumption has grown consistently since humans first burned wood to roast meat, and growth in energy usage is robust today: in just 17 years starting from 1990, total primary energy consumption worldwide has grown 31% to 456 quadrillion BTU (quads) in 2007 (see Figure 1). While the faltering of the world economy has depressed industrial production, consumer activity, and travel since 2007, it’s clear from the rise of population and energy needs in emerging economies like Brazil, China, and India that this retreat will just be a temporary hiccup. While growing energy usage has lifted living standards and helped deliver all the goods of modern life, it’s becoming clear that our ever-increasing consumption in energy is unsustainable.

Figure 1: Global primary energy consumption grew 31% between 1990-2007.

Due to the risks posed by swelling energy consumption, inventors, investors, and entrepreneurs have turned their efforts towards ways of improving energy efficiency — whether through better engines, a smarter power grid, or more economical equipment and appliances. Policymakers have thrown their support behind such goals, with efforts such as the US’s Advanced Research Projects Agency — Energy (ARPA-E), Japan’s New Energy and Industrial Technology Development Organization (NEDO), and Germany’s National Energy Efficiency Action Plan (NEEAP). Developers of nanomaterial-based technologies are no exception, seeking to turn up ways nanoscale materials’ unique properties can help trim energy needs.

Efficiency is the path of least resistance

To avoid an energy crisis, nations like the US, Japan, and Germany could opt for one of two unpalatable choices. They can try to legally enforce conservation, which irritates many citizens who are accustomed to the benefits they gain from their energy usage. Alternatively, they can build out production capabilities for renewable energy sources, but many of these technologies are still young, and the prices of renewable energy are usually uncompetitive when subsidies are removed from the equation. There’s a third option, however: pursuing energy efficiency, which can shave off consumption without requiring austerity measures from users.

As an enabling technology for many applications, nanotechnology can be a potent tool for enhancing the efficiency of both new and existing devices and processes. While most of the attention given to nanomaterials for energy applications has been devoted to energy production and storage, there has also been much work on improving the energy outlook from the demand side as well. With a decade of serious government, corporate, and venture capital investment under its belt (see the report "Ranking the Nations on Nanotech: Hidden Havens and False Threats"), the field has generated many nano-enabled products that can improve energy efficiency and are already commercial and on the market. In this report we assess the impact of six products in particular (see Figure 2).

Figure 2: Six products rein in energy consumption in all four sectors.

Nanotech’s potential belies its size

We use the examples of the US, Germany, and Japan as three case studies to discuss the impact these nano-enabled products on energy consumption. As a starting point, we set out to quantify the total opportunity these six products posed for reducing energy consumption, assuming they achieve their full potential and 100% adoption. We found that these innovations alone could in principle reduce overall final energy consumption (FEC) in the US, Germany, and Japan by 10.9%, 13.9%, and 9.2% respectively in 2020 (see Figure 3).

Figure 3: Full adoption promises enormous impact.

Full adoption, while useful for quantifying opportunities, is an unrealistic assumption and therefore not a good indicator for the future. To provide a more accurate determination of the impacts of these products, we built reasonable adoption scenarios for the six products by dropping them into buckets for 10%, 25%, and 50% saturation points and 10-year, 20-year, and 30-year adoption cycles, and then reanalyzed their effects on energy consumption. Note that this calculation is not an attempt to precisely forecast the market, but rather to make reasonable assumptions that allowed us to provide a realistic portrait of the future.

Under these new realistic adoption scenarios, all three countries coincidentally reduce FEC by about 1.6% (see Figure 4). As was the case under full adoption assumptions, the US, Germany, and Japan all benefited differently from these six nano-enabled products. Cumulatively, reductions from lighting and from automotive lightweighting through composites had the most effect, constituting about 40% and 27% of the realized energy savings from the three countries respectively.

Figure 4: Savings are severely reduced under realistic adoption scenarios.

Worries about energy needs are growing to a fever pitch, but virtually everywhere in the world energy demand continues to rise. Meeting this demand with cleaner or more secure energy sources can help assuage some worries, but the relentless upward march of energy usage makes for an intimidating challenge. Combined with other energy efficiency measures, from the smart grid to hybrid electric vehicles, nano-enabled products can help trim away at energy needs, dropping CO2 emissions, limiting environmental impacts, and mitigating cost and security concerns around conventional energy sources. Other challenges abound, of course: the developing world’s booming energy demand will be tougher to trim; penetration of renewables will still need to accelerate to seriously dent fossil fuels’ energy dominance. But nano-enabled products that advance energy efficiency will play a strong part in managing looming energy challenges — creating solid business opportunities along the way.


David Hwang received a BSE in Bioengineering from the University of Pennsylvania and is an analyst at Lux Research Inc. His full report on nanotech’s answer to the energy problem is "Nanotech’s Answer Key to the Energy Problem ".

EnerG2 is a recent start-up focused on customizing electrode materials to enhance energy and power density in ultracapacitors, used for energy storage. The company is using nano-structured materials to optimize the electrodes’ surface area, which they say will help performance and cycle life. In August, EnerG2 broke ground on what they claim to be the world’s first facility dedicated to the commercial-scale production of synthetic high-performance carbon electrode material. The plant was made possible by a $21.3 million Federal stimulus grant allocated by the U.S. Department of Energy for makers of advanced automotive batteries and energy storage technologies. EnerG2 will partner with Albany-based Oregon Freeze Dry, Inc. (OFD).

In addition to the federal stimulus funding, EnerG2 since inception seven years ago has raised over $14.5 million in equity financing. Institutional investors OVP and Firelake led a Series A financing and additional strategic investors added new equity funding in April of this year.

 

Caption: EnerG2’s carbons demonstrate a spectrum of pore size distributions and surface morphologies. The technology is based on molecular self-assembly and produces nano-structured carbon materials that are finely controlled and offer ultra-high surface areas.

The company uses nano-structured carbon materials that are finely controlled and offer ultra-high surface areas. These materials are extremely conductive and are tremendously attractive to energy-storing molecules such as electrolytic ions, methane, natural gas and hydrogen.

It is this kind of technology development that a DoE panel called for in 2007. In their findings, published in the Basic Research Needs for Electrical Energy Storage, the panel said the capability to synthesize nanostructured electrodes with tailored, high-surface-area architectures offers the potential for storing multiple charges at a single site, increasing charge density. The addition of surface functionalities could also contribute to high and reproducible charge storage capabilities, as well as rapid charge-discharge functions. They predicted that the design of new materials with tailored architectures optimized for effective capacitive charge storage will be catalyzed by new computational and analytical tools that can provide the needed foundation for the rational design of these multifunctional materials. "These tools will also provide the molecular-level insights required to establish the physical and chemical criteria for attaining higher voltages, higher ionic conductivity, and wide electrochemical and thermal stability in electrolytes," they said.

Ultracapacitors are a type of electrochemical capacitors (ECs), which differ from conventional dielectric and electrolytic capacitors in that they store far more energy. As energy storage devices, ECs have a number of potentially high-impact characteristics, such as fast charging (within seconds), reliability, large number of charge-discharge cycles (hundreds of thousands), and wide operating temperatures. Because of their very fast charging rate, ECs may be able to recover the energy from many repetitive processes (e.g., braking in cars or descending elevators) that is currently being wasted. Large-scale ECs can perform functions of a different kind, such as power quality regulation of the electrical grid, which can avoid the costly shutdown of industrial operations as a result of intermittent outages and power fluctuations.

While ECs are related to batteries, they use a different energy storage mechanism. Batteries move charged chemical species (ions) from one electrode via an electrolyte to the second electrode, where they interact chemically. Thus batteries store chemical energy. EDLCs store electrical charge physically, without
chemical reactions taking place. Because the charge is stored physically, with no chemical or phase changes taking place, the process is highly reversible and the discharge-charge cycle can be repeated virtually without limit. Typically, an EDLC stores electrical charge in an electrical double layer in an electrode-electrolyte interface of high surface area. Because of the high surface area and the extremely low thickness of the double layer, these devices can have extraordinarily high specific and volumetric capacitances. A striking dissimilarity between batteries and ECs is the number of charge-discharge cycles each can undergo before failure. The dimensional and phase changes occurring in battery electrodes represent one of the key limitations in attaining longer charge-discharge cycling. In contrast, no inherent physical or chemical changes occur in EC electrodes during cycling because the charge is stored electrostatically. As a result, ECs exhibit cycle lifetimes ranging from a few hundred thousand to over one million cycles. Most notably, however, ECs have the ability to deliver an order of magnitude more power than batteries.

Originally working in collaboration with the University of Washington Department of Materials Science & Engineering, EnerG2 has developed and commercialized unique sol-gel processing technologies to construct its carbon materials (from the EnerG2 website). Sol-gel processing, which creates optimal structure and purity in the finished carbon product, is a chemical synthesis that gels colloidal suspensions to form solids through heat and catalysts.

EnerG2 has invented a patented ability to control the hydrolysis and condensation reactions within the gelling process, allowing the materials’ surface structures and pore-size distributions to be shaped, molded and customized. The company says it has developed these processing capabilities with an explicit and aggressive focus on cost control. To avoid the expensive processing typically associated with nanotechnology, the company has leveraged large-scale commercial processing technologies from established industries to design a production approach that is both relatively inexpensive and inherently scalable.

In addition to ultracapacitor electrodes, the company is targeting fuel cell and hydrogen storage applications.

(November 18, 2010 – BUSINESS WIRE) — Dan Siewiorek, Karen Lightman, Rich Duncombe, Vida Ilderem, and other speakers from the MEMS industry shared their visions for the future at the MEMS Executive Congress 2010. Following are summaries of their talks, from the "iPhone 20" lifetime smart-companion to seisic imaging developments, energy management, and more MEMS opportunities.

In Dan Siewiorek’s vision of the future, each of us will get an "iPhone 20" at birth. Powered by a wide range of microelectromechanical systems, or MEMS, this personalized mobile device will monitor your heart rate when you exercise, help the visually impaired to grocery-shop, and remember important social clues such as people’s names, phone numbers and directions. More of a “friend for life” than a smartphone, this intelligent device will help you to navigate your environment and will sustain you on a daily basis as you age. As a professor of computer science and electrical and computer engineering at Carnegie Mellon University’s Quality of Life Center, Dr. Siewiorek has unique insight into the practical applications of MEMS sensors and contextual software for mobile phones and wearable pendants. While addressing an audience of more than 180 business executives at the 6th annual MEMS Executive Congress on November 4th, Siewiorek and his fellow panelists claimed the attention of MEMS suppliers looking for new business opportunities as well as leading OEMs eager to learn more about the commercial applications of MEMS technology.

“At MEMS Executive Congress, OEMs and end users have a conversation with the MEMS industry about emerging trends and business opportunities,” said Karen Lightman, managing director of the event’s host organization, MEMS Industry Group. "During this year’s forum, market analysts shared their latest research on what’s hot and what’s not, with an eye to market growth through 2015. Industry experts in consumer electronics, quality of life/robotics, and energy dove into the short- and long-term commercial uses of MEMS. And keynote speakers from HP and Intel offered an inside look at how two top technology companies see practical applications for MEMS within their own organizations and the global IT infrastructure.”

In his opening keynote address, Rich Duncombe, strategist, Technology Development Organization, Imaging and Printing Group, HP, reflected on the business processes behind his latest disruptive technology launch: “While the creative energy behind innovation may seem like ‘magic,’ innovation at HP results from a disciplined business development process. We innovate from our core, incorporating client-focused innovation to deliver an end-to-end solution.”

HP’s latest achievement is a wireless seismic imaging system featuring one million sensor nodes based on accelerometers that are up to 1000x more sensitive than today’s consumer-centric accelerometers. Developed in collaboration with Shell, the new system uses high-resolution seismic data to locate difficult-to-find oil and gas reservoirs.

In her closing keynote address, Vida Ilderem, Ph.D., vice president of Intel Labs and director of the Integrated Platform Research Lab for Intel Corporation, wrapped up MEMS Executive Congress with some concluding thoughts: “The technology industry at large is realizing a greater mobility vision, one that encompasses mobile platforms and architectures, pervasive connectivity, context awareness and human-computer interaction.”

Identifying sensor-intensive applications such as mobile augmented reality devices and ‘personal energy systems’ for homes, offices and college campuses, Dr. Ilderem encouraged the audience to increase sensor intelligence and ease sensor integration to meet the requirements of these emerging context-aware systems.

More voices from MEMS Executive Congress
Dean Samara-Rubio, PhD, platform architect, Energy and Utilities, Intel, believes that “we need sensing, communications, data structures and analytics in order to build an integrated node to make a truly smart home that engages the homeowner. Once we integrate this sensing capability into easily managed and interpreted systems, we may begin to make inroads into smart homes and smarter commercial buildings.”

Cleo Cabuz, CTO, Life Safety, Honeywell, highlighted energy harvesting as a significant opportunity for MEMS: “With a strong portfolio of commercially-available energy harvesting devices for wireless sensors used in home and building automation, we see widespread future potential for small, low power MEMS sensors, using energy harvested from power lines, from light switches and even from gas and air flow devices.”

One of the event’s energy success stories came from Liji Huang, PhD, founder, president and CEO, Siargo Ltd. Through MEMS-flow sensing technology, Siargo’s smart gas meters have their first commercial win. Siargo has shipped its MEMS utility gas meters to more than 17 gas companies (including China Petro) since 2008. Most recently Siargo signed a strategic agreement with Asia’s largest utility gas company, Hong Kong Towngas, to further develop and deploy this technology to its more than 11 million customers.

Jungkee Lee, PhD, principal engineer, director of Telecommunication Module Lab, Samsung, astounded Congress attendees through a use of MEMS never imagined. Dr. Lee demonstrated Samsung’s Galaxy Beam mobile phone (GT-I8520) with integrated pico projector — which employs Texas Instruments DLP pico chipset. He pointed out that another DLP-based pico-projector phone, the GT-I7410, shed some light into the lives of the trapped Chilean miners, allowing them to watch soccer games and other visual content via projected images generated by the Samsung phone.

Greg Turetzky, senior marketing director, CSR, emphasized the value of MEMS as part of a whole platform: "New classes of applications that include GPS, communication and MEMS — all integrated via software — are extremely compelling. One example might be shoes featuring an embedded GPS receiver, small MEMS sensor and mobile phone transmitter. Such ‘smart’ shoes could be used to track the whereabouts of children and Alzheimer’s patients."

“We set records at MEMS Executive Congress this year, with more overall attendees and an even stronger international representation,” offered Ms. Lightman. “With top-notch keynotes and high-caliber panels, our speakers conveyed the wealth of opportunities in MEMS technology and MEMS-enabled applications. Our attendees responded with enthusiasm, engaging with speakers in formal and informal networking venues. We have truly raised the bar for our 2011 MEMS Executive Congress!”

MEMS Executive Congress is an annual event that brings together business leaders from a broad spectrum of industries: automotive, consumer goods, energy/environmental, industrial, medical and telecom. It is a unique professional forum at which executives from companies designing and manufacturing MEMS technology sit side-by-side with their end-user customers in panel discussions and networking events to exchange ideas and information about the use of MEMS in commercial applications.

Sponsors of MEMS Executive Congress 2010 included: A.M. Fitzgerald & Associates, Analog Devices, ANSYS, Bosch Sensortec, DALSA, EV Group, Freescale Semiconductor, iSuppli, Lam Research, MEMS Investor Journal, Maxim, Okmetic, Plan Optik, SPP Process Technology Systems (SPTS), SUSS MicroTec, SVTC, Tegal Corporation and Yole Développement.

MEMS Executive Congress 2010 was held November 3-4, 2010 at the InterContinental Montelucia Resort & Spa in Scottsdale, Arizona. MEMS Executive Congress 2011 will be held November 2-3, 2011 at the Monterey Plaza Hotel and Spa. For more information, please contact MIG via phone: 412/390-1644, email: [email protected] or visit MEMS Executive Congress at: www.memscongress.com.

MEMS Industry Group (MIG) is the trade association advancing MEMS across global markets. MIG enables the exchange of non-proprietary information among members; provides reliable industry data that furthers the development of technology; and works toward the greater commercial development and use of MEMS and MEMS-enabled devices. More than 100 companies comprise MIG, including Analog Devices, Applied Materials, Bosch Sensortec, Freescale Semiconductor, GE, GLOBALFOUNDRIES, Honeywell, Intel, OEM Group, Plures Technologies, Rite Track, Tecnisco and Texas Instruments. For more information, visit www.memsindustrygroup.org.

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(November 18, 2010) — A group of European defense integrators and photonics clusters has today launched a Business Round Table for Photonics Sensors for Defense and Security. The mission of this Round Table is to create business relationships between photonics small/medium-sized enterprises (SMEs) that are leaders in sensor innovations and technology integrators who are seeking specific capabilities and performance for defense and security systems. The Round Table will accelerate the presence in the market of key competitive sensor technologies in defense and security applications. Interested defense systems manufacturers and photonics clusters are invited to join this initiative.

Jean-François Coutris, VP of SAGEM Defense and Security, contributed to the organization of this initiative. "SMEs are strong in technology innovation. They are both agile and inventive and can work on developments that larger industries could not afford to invest in. We must facilitate the development of these SMEs that are crucial to our competitive position."

Thomas Pearsall, secretary general of the European Photonics Industry Consortium, (EPIC) also a partner in the organization of the Business Round Table added, "The defense majors, like MBDA and SAGEM, are strong in technology integration. They have the resources and the know-how for integrating new technology into reliable and performant systems coupled with a good view of market opportunities."

The Business Round Table is planning meetings four times per year in different locations around Europe.  SMEs will be invited to present innovations in sensor technology, and defense integrators will discuss needs for sensing systems. Participants from both sides will be able to discuss details in networking sessions during the meeting. W. Knorr, head of the laser division of the binational French/German research institute of Saint Louis, appreciates the launch of the Photonics Sensors Business Roundtable: "This is an important positive step in accelerating the exploitation of new photonics sensor applications in Europe."

SMEs who would like to participate should contact the photonics cluster in their region.  These clusters will decide on the participants’ program. Defense and security integrators who wish to participate should contact EPIC directly.

Thirteen photonics clusters:

  • Anticipa, France
  • Cluster Photonique, Belgium
  • Estonian Photonics, Estonia                
  • EPIC, EU
  • Heinrich-Hertz Institute, Germany                           
  • OpticsValley, France                 
  • Optoelectronics Research Center, Finland                
  • OptecBB, Germany           
  • POP Sud, France 
  • Rhenaphotonics Alsace, France
  • Route des Lasers, France 
  • SECPHO, Spain                   
  • Swiss Laser Net, Switzerland       
  • Scottish Optoelectronics Association, UK
  • Electronics, Sensors, Photonics KTN, UK
  • Wroclaw Photonics Cluster, Poland

and three defense majors :

  • INDRA, Spain
  • MBDA, UK
  • SAGEM, France

formed the group of initiating charter members.  Participation from other interested members of the community, either clusters or defense systems integrators is solicited.

Contact Martine Keim-Paray, EPIC, 17, rue de l’Amiral Hamelin, 75016 Paris, France; [email protected]; www.photonics-sensors.eu

Also read: EuroPIC: European manufacturing consortium for photonic integrated circuits

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(November 17, 2010) — University of California, San Diego NanoEngineers won a grant from the National Institutes of Health (NIH) to develop the tools to manufacture biodegradable frames around which heart tissues — functional blood vessels included — will grow. Developing methods for growing tissues that mimic nature’s fine-grained details, including vasculature, could lead to breakthroughs in efforts to grow replacement cardiac tissues for people who have suffered a heart attack. The work could also lead to better systems for growing and studying cells, including stem cells, in the laboratory.

Figure 1. Scanning electron microscopy (SEM) image of a scaffold with a honeycomb pore design that Shaochen Chen and colleagues created using an older version of Shaochen Chen’s scaffold manufacturing platform.

Professor Shaochen Chen from the UC San Diego Department of NanoEngineering is the Principal Investigator on the four-year $1.5 million grant from the National Institutes of Health. The grant is funding development of the manufacturing platform necessary to produce these biodegradable frames or “scaffolds.”

“We are creating biomaterials with nanostructures on the inside,” said Chen. “Scientifically there are so many opportunities at the molecular level, and nanoengineering is a perfect fit for that. We expect our new biofabrication platform will yield tissues that mimic natural tissues much more closely.”

One such opportunity is to add new levels of precision and functionality to the scaffolds produced by the “biofabrication platform” that Chen and his collaborators invented and have been improving over the last five years.

With the improved biofabrication platform, engineers in the Department of NanoEngineering within the UC San Diego Jacobs School of Engineering will be able to produce scaffolds with precisely designed systems of nanoscale pores and other microarchitectural details that control how cells interact with each other and with the environment.

“You need to design the pores so the cell can get nutrition and dump waste…pathways for the cell to survive in the system,” explained Chen. 

Figure 2. Scanning electron microscopy (SEM) image of a scaffold with a triangle pore design that Shaochen Chen and colleagues created using an older version of Shaochen Chen’s scaffold manufacturing platform.

The researchers also plan to create scaffolds with tubes, and then seed those tubes with the cells that line blood vessels — endothelial cells — to try to generate functioning vascular systems. The lack of blood vessels in most tissue regeneration systems results in cell death, loss of function, and limits the maximum size of regenerated tissues.

In addition, the chemical properties of the new scaffolds will change from top to bottom, which will create chemical gradients that drive cell growth.

As in previous versions of Chen’s scaffold-building system, cells will be encapsulated within scaffold walls.

“Usually, when researchers grow tissue, they make a scaffold, put the cells in the scaffold and let the cells grow,” explained Chen. “When we fabricate our scaffolds, the cells are already inside the scaffold walls.” Encapsulating cells within the walls encourages uniform seeding of cells.

The scaffolds will be based on natural materials such as hyaluronic acid, a key component of the “extracellular matrix” that provides structural support, wound healing, and a range of other functions to human and other animal tissues. "The hydrogels for our scaffolds can’t be too soft, too sticky or too rigid. They need to fit the needs of the biological tissue," said Chen. Collaborators at Harvard Medical School will grow and characterize the tissues started on the scaffolds.

To manufacture tissue scaffolds, Chen and colleagues have developed and continue to refine a manufacturing process that uses light, precisely controlled mirrors, and a computer projection system. First, the engineers design a three dimensional model of the structure to be printed. Next, the engineers prepare a solution containing both the cells that will eventually grow into the tissue and the polymers that will solidify into the scaffold. When light shines into the solution using the series of mirrors, the scaffold solidifies according to the exact specifications of the projected image. Following these steps, scaffolds are manufactured and cells are encapsulated in scaffold walls as light solidifies the polymers one layer at a time.

"With our biofabrication platform, we can build arbitrary, three-dimensional shapes, like branches of blood vessels, and tubes — large and small," said Chen. "My focus is on the materials fabrication and devices level. This work is applicable to many different types of cells and tissues."

Learn more at http://www.ucsd.edu/

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(November 17, 2010) — While offering great promise in a host of new applications, carbon nanotubes (CNTs) could be harmful to humans and a new risk review suggests product designers and others should provisionally treat CNTs "as if" they are hazardous.

Because environmental and health information on CNTs is incomplete and sometimes conflicting, an "anticipatory governance" approach to the technology is needed, according to Mark Philbrick of the Center of Integrated Nanomechanical Systems at the University of California, Berkeley. Anticipatory governance is an approach designed to support decision makers where there is uncertainty about safety, a common situation when managing emerging technologies.

Attend the on-demand webcast, "Understanding Nanotechnology Safety" now

Given the "conflicted character of the data," how "relevant actors" should respond is the central question Philbrick asks in developing strategies for utilizing CNTs. He asserts that treating carbon nanotubes "as if" they are hazardous implies limiting exposure throughout product life-cycles. This means implementing strong engineering controls for CNT research and manufacturing, avoiding applications where CNTs would be routinely released to the environment, and planning for recycling at the end of a product’s useful life. The article also argues, "The anticipatory governance approach is particularly important as innovation rates in nanotechnologies exceed our capacity to assess human and environmental consequences of these innovations, especially when deployed at commercial scales…it helps identify uncertainties in our knowledge and focuses future research to address those gaps." 

The research was funded by the National Science Foundation and  conclusions are detailed in Philbrick’s article, "An Anticipatory Governance Approach to Carbon Nanotubes," in the November issue of the journal Risk Analysis published by the Society for Risk Analysis. The entire November issue is devoted to risk analysis articles related to nanotechnology.

An anticipatory approach is particularly important until the toxicity and behavior of CNTs in the environment are better understood, especially as they can remain airborne for extended periods, and share some characteristics with asbestos. While a few rodent studies have found similarities between the health effects of inhaling both substances, there is not enough data to draw firm conclusions.

The article notes the promise held out by CNTs is immense: some types conduct electricity and heat better than copper, others are stronger than steel while weighing less than aluminum, and yet others could be used in targeted drug delivery. These properties could find uses in aircraft frames, sensors, and electrical transmission. Nevertheless, treating them "as if" they are hazardous is a prudent course of action given uncertainty about their potential health consequences, the author said. 

Risk Analysis: An International Journal is published by the nonprofit Society for Risk Analysis (SRA). SRA is a multidisciplinary, interdisciplinary, scholarly, international society that provides an open forum for all those who are interested in risk analysis. Risk analysis is broadly defined to include risk assessment, risk characterization, risk communication, risk management, and policy relating to risk, in the context of risks of concern to individuals, to public and private sector organizations, and to society at a local, regional, national, or global level. www.sra.org

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(November 16, 2010) — Metallic and semiconducting single-wall carbon nanotubes (SWCNT) can be distinguished using a new imaging tool for rapidly screening the structures, researched at the Weldon School of Biomedical Engineering, Purdue University. The technology may hasten the use of nanotubes in creating a new class of computers and electronics that are faster and consume less power than those in use today.

Metallic versions form unavoidably during the CNT manufacturing process, contaminating the semiconducting nanotubes. Now researchers have discovered that an advanced imaging technology could solve this problem, said Ji-Xin Cheng, an associate professor of biomedical engineering and chemistry at Purdue University. "The imaging system uses a pulsing laser to deposit energy into the nanotubes, pumping the nanotubes from a ground state to an excited state," he said. "Then, another laser called a probe senses the excited nanotubes and reveals the contrast between metallic and semiconductor tubes."

The technique, called transient absorption, measures the "metallicity" of the tubes. The detection method might be combined with another laser to zap the unwanted metallic nanotubes as they roll off of the manufacturing line, leaving only the semiconducting tubes.

Findings are detailed in a research paper, "Fast Mapping of Metallicity in Individual Single-Walled Carbon Nanotubes Using a Transient Absorption Optical Microscope" appearing online this week in the journal Physical Review Letters and authored by Purdue physics doctoral student Yookyung Jung; biomedical engineering research scientist Mikhail N. Slipchenko; Chang-Hua Liu, an electrical engineering graduate student at the University of Michigan; Alexander E. Ribbe, manager of the Nanotechnology Group in Purdue’s Department of Chemistry; Zhaohui Zhong, an assistant professor of electrical engineering and computer science at Michigan; and Yang and Cheng. The Michigan researchers produced the nanotubes.

Single-wall nanotubes are formed by rolling up a one-atom-thick layer of graphite called graphene, which could eventually rival silicon as a basis for computer chips. In spite of the outstanding properties of single-walled carbon nanotubes, the co-existence of metallic and semiconducting SWCNTs as a result of synthesis has hindered their electronic and photonic applications. Researchers in Cheng’s group, working with nanomaterials for biomedical studies, were puzzled when they noticed the metallic nanoparticles and semiconducting nanowires transmitted and absorbed light differently after being exposed to the pulsing laser. Researcher Chen Yang, a Purdue assistant professor of physical chemistry, suggested the method might be used to screen the nanotubes for nanoelectronics.

"When you make nanocircuits, you only want the semiconducting ones, so it’s very important to have a method to identify the metallic nanotubes," Yang said.

The nanotubes have a diameter of about 1 nanometer, or roughly the length of 10 hydrogen atoms strung together, making them far too small to be seen with a conventional light microscope. "They can be seen with an atomic force microscope, but this only tells you the morphology and surface features, not the metallic state of the nanotube," Cheng said.

The transient absorption imaging technique represents the only rapid method for telling the difference between the two types of nanotubes. The technique is "label free," meaning it does not require that the nanotubes be marked with dyes, making it potentially practical for manufacturing, he added.

The researchers performed the technique with nanotubes placed on a glass surface. Future work will focus on performing the imaging when nanotubes are on a silicon surface to determine how well it would work in industrial applications.

"We have begun this work on a silicon substrate, and preliminary results are very good," Cheng said.

Future research also may study how electrons travel inside individual nanotubes.

The research is funded by the National Science Foundation. Learn more at https://engineering.purdue.edu/BME/, Weldon School of Biomedical Engineering

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