Tag Archives: Small Times Magazine

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Feb. 15, 2006 – Private funding works a certain way. Entrepreneurs bootstrap their moonlight tinkerings into small startups. They raise early financing from friends, family and angel investors. They go to venture capitalists. But a couple of companies actively funding nanotech are not so certain that’s the best way after all.

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Instead, they are breaking the rules and raising money on public markets to sponsor university-level research in hopes of spinning out nano startups. These early stakes, they claim, will help them and their investors profit the most if they strike pay dirt.

However, they also share a set of challenges: holding the long-term attention of investors seeking quarterly results, justifying a stock price without a revenue stream, and rolling nascent technologies into revenue-producing companies fast enough to avoid having to give away lots of equity or pour money into years of expensive product development.

The basic business models of both Arrowhead Research (Nasdaq: ARWR) and Advance Nanotech (OTC.BB: AVNA) are strikingly similar. Both companies are sponsoring research at the university level in exchange for rights to commercialize the intellectual property that results. When the technologies are ready to leave the lab, say the executives in charge of the firms, they will form operating subsidiaries or spin off startups and then provide additional financing and support services and, if necessary, organize a broader investor syndicate for a follow-on round.

“A lot of corporations used to do their own research,” said Bruce Stewart, chairman and chief executive officer of Pasadena, Calif.-based Arrowhead. “What they’re doing now is saying, ‘Let the entrepreneurs do it.’ … The real research today is in universities.”

Stewart said he can secure exclusive rights to leading-edge university research for between $200,000 and $250,000 per year — a price he considers a bargain. Arrowhead has three operating subsidiary companies and three sponsored research efforts. The company is also building a firm, NanoPolaris, that is attempting to aggregate intellectual property in the field of carbon nanotubes.

Magnus Gittins, president and CEO of New York-based Advance Nanotech, sees the opportunity similarly: In his company’s case, he said it costs about $300,000 per year. One Advance Nanotech subsidiary, Cambridge, England-based Owlstone Nanotech, recently emerged and Gittins said two others are being prepared to be unveiled over the next year. Advance Nanotech claims 15 separate technology partnerships with University of Cambridge and Imperial College London as well as a minority interest in Singular ID Pte. of Singapore.

Arrowhead’s Stewart recently hired Virginia Dadey, a former investment bank sales executive, as vice president of investor relations in order to address the first problem: Shore up an institutional base to better maintain investor interest over the long haul.

Dadey said Arrowhead is being proactive about presenting at industry conferences and is trying to communicate the company’s message to the stock analyst community. And, of course, she is speaking with the institutional investors, hedge funds and other funds that she wants to recruit as investors in the firm.

By December, the company had managed to attract 11 institutional investors, accounting for 10.8 percent of the outstanding shares, according to the Nasdaq market. However, most of that — 9.2 percent — was held by one company. By contrast, the stock of Harris & Harris Corp. (Nasdaq: TINY), a publicly traded venture capital firm that specializes in nanotechnology, MEMS and microsystems, had 58 institutional investors in early December, more than 26 percent of its outstanding shares and a much more stable base of investors.

“It’s not for everybody,” Dadey acknowledged, but said she expects the initial resistance to give way as nanotech companies make more quantifiable achievements. Meanwhile, Stewart said he is beginning to receive inquiries from hedge funds and other large investors.

Advance Nanotech has been slower out of the gate. By early December it had no institutional investors, according to the Nasdaq. CEO Gittins said he spends upwards of two days per week with investment firms. “I believe we have been able to craft a quite unique message,” he said.

He agreed with Dadey that communication is a crucial part of the necessary strategy. “When you’re listed on a junior exchange and you’re a micro cap company you have to really get out and tell the story,” Gittins said. In the last year, he added, “there is more of an appetite for listening to stories about disruptive technologies that will enable new markets.”

And he thinks the job will be easier once portfolio companies prove their mettle. “Once we monetize the Owlstone asset it will provide credibility to me and my management team,” he said.

And, by reference, the stock. Without revenues, profits or other quarterly metrics by which to measure their progress, it will be difficult for investors to justify a certain price, and likewise a challenge for analysts who might be interested in following the companies to set price targets.

However, both Stewart and Gittins acknowledge that moving technologies out of the lab and into product companies will likely be their biggest challenge. What began as a bargain becomes an expensive proposition once they create and staff companies around the technologies, they said.

Already, Arrowhead faced such a situation. After realizing that one of its initial subsidiaries, Nanotechnica, was going to take longer to develop its technology than originally anticipated, Arrowhead shut it down last summer rather than pony up the $16 million it had contemplated investing.

“We pulled Nanotechnica out of the lab and into the market prematurely,” Stewart said. “Now we leave (the technology) in the university for as long as we can.”

In response, Dadey said Arrowhead has tweaked its model to fund only what she characterized as “late stage investments” — that is, university technologies that are almost at a prototype stage. She said that might mean 12 to 24 months to develop a research product and another year for a commercial one.

Gittins said his company also intends to keep technologies in the university setting as long as possible to keep costs down. And, he has hired a trio of industry experts with real-world experience commercializing products in the materials, electronics and life science sectors.

Doubtless such expertise will help. And if they are successful in getting past the so-called valley of death between prototypes and revenues it will be that much more of an accomplishment — because it’s not just any old rule that these companies are breaking, but rather one of the cardinal rules of private equity: Don’t fund science projects.

Feb. 15, 2006 – Acrongenomics Inc. announced Tuesday the appointments of Constantine Poulios as president and Platon Tzouvalis as vice president. Poulios will replace Eleftherios Georgakopoulos, who retired earlier this week.

The company also announced negotiations with unnamed parties on a collaboration agreement for the development of “nanoweapons” to combat hospital related infections. Acrongenomics, a research & development company based in Greece, is pioneering nanobiotechnology applications for the medical community.

Feb. 15, 2006 – Nanosphere Inc., a nanotechnology-based molecular diagnostics company, and Applied NeuroSolutions Inc. (OTCBB:APNS), a company focused on the development of an integrated product portfolio for the diagnosis and treatment of Alzheimer’s disease, announced this week a research collaboration for the development of diagnostic tests for Alzheimer’s disease. Both companies are based in Illinois.

This research program will apply Nanosphere’s proprietary Biobarcode(TM) technology for protein detection to Applied NeuroSolutions’ proprietary biomarkers, which have been shown to be 85 to 95 percent accurate in the detection of Alzheimer’s disease. Ultra-sensitive detection of these markers has the potential to lead to the next generation of diagnostic tests for Alzheimer’s disease.

Feb. 14, 2006 – Molecular Nanosystems, Inc., a developer of chemical vapor deposition technology for the semiconductor industry, announced Monday that Srinivas Rao has joined the company as CEO and CTO, and Ken Goodson has joined the company’s technical advisory board.

The company has also closed a round of angel financing that will support getting its patent-protected thermal management solutions to market after five years of exploration and development.

Feb. 13, 2006 — Acacia Research Corp. (Nasdaq:CBMX) (Nasdaq:ACTG) announced Monday that its CombiMatrix group has begun work on a one year, $2.1 million contract with the U.S. Department of Defense (DoD). Funding for this contract was previously announced as part of the DoD budget.

CombiMatrix’s development program with the Department of Defense is focused on the integration of CombiMatrix’s biotechnology with microelectronics and microfluidics and the development of an automated system. CombiMatrix is seeking to develop systems for a broad range of requirements from portable hand-held devices to larger industrial units. CombiMatrix’s integrated detection system is targeting potential threats such as Anthrax, plague, toxins, and other agents that could be used as bioweapons by terrorists and other enemies.

Luna Innovations files for IPO


February 13, 2006

Feb. 13, 2006 – Luna Innovations Inc. of Roanoke, Va., announced Friday that it has filed a registration statement with the U.S. Securities and Exchange Commission relating to the proposed initial public offering of its common stock. The number of shares to be offered and the price range for the offering have not yet been determined. All shares of the common stock to be sold in the offering will be offered by the company. The company has applied to list its shares of common stock on the Nasdaq National Market under the proposed trading symbol “LUNA”.

ThinkEquity Partners LLC will be acting as the sole book-running manager. WR Hambrecht + Co and Merriman Curhan Ford & Co. will be co-managers for the offering.

Luna Innovations researches, develops and commercializes technologies in molecular technology and sensing solutions.

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The challenge: Secure Food and Drug Administration approval to put a new type of device or material inside the human body.
The approach: Both CardioMEMS and AcryMed combined rigorous trials with early and constant communication with the FDA.
The result: CardioMEMS’ EndoSure Wireless AAA Pressure Measurement System received FDA approval in November. A catheter using AcryMed’s SilvaGard coating was approved in December.

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Feb. 13, 2006 – Developing a new product — matching design and functionality with a real market need — is difficult enough. But when it comes to working inside the human body, it’s doubly so. Devices and materials used in vivo must undergo rigorous clinical trials in what is essentially a make-or-break process. Two recent success stories, one a MEMS company and the other a nanotech company, highlight some of the best practices companies use to navigate the trials process.

Both companies — CardioMEMS of Atlanta and AcryMed of Portland, Ore. — saw their products receive FDA approval late last year. CardioMEMS makes implantable MEMS medical sensors. AcryMed makes antibacterial nanoparticle coatings for medical devices. In both cases, said executives at the firms, getting in touch with the FDA early on proved critical, as did clear communication and a collaborative attitude.

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CardioMEMS’ implantable sensor is designed for use with stents that treat an aneurism of the lower abdominal aorta. In the condition, a weakened aortal wall begins to bubble out, a potentially catastrophic problem if it bursts. Currently, stents with a fabric coating are implanted within the artery to create a sort of tube-within-a-tube. When functioning correctly, the blood flows through the tube and the pressure on the arterial wall is alleviated.

However, leaks appear periodically when blood finds its way around the stent, putting pressure back on the damaged wall. Currently, patients must undergo CT scans on a regular basis to test for leaks. With CardioMEMS’ sensor, however, a doctor merely has to move a handheld antenna over the patient’s abdomen to determine whether there is any pressure on the sensor, which has been implanted into the aneurysm sac during the same procedure in which the stent was placed in the body.

In addition to the challenge of developing an innovative technology that combines MEMS sensors, wireless connectivity and proprietary software, “we also had to demonstrate to the FDA that the product is both safe and effective since we are a medical device company,” said David Stern, CardioMEMS’ chief executive.

To streamline the process, Stern said his company stayed in constant communication with the FDA and hired a director of regulatory affairs to be responsible for the effort. Clinical tests began in March 2004 in Brazil and ultimately also included Argentina, Canada and the United States.

For starters, CardioMEMS’ sensor is built on a ceramic silica substrate, he said. To prove its product’s safety, the company had to do extensive research to show that all the materials it used were biocompatible and also extremely stable.

Meanwhile, interesting questions popped up — like, how do you confirm that the device is always functioning correctly? After all, if the stent is doing its job, there may be little or no pressure in the aneurysm sac. It is important that physicians do not misinterpret a “zero” pressure reading as a non-responsive sensor.

Stern explained that as long as the antenna is receiving a frequency signal from the sensor, the physician can be assured that the device is working properly. Just the same, the company still developed a simple test to use during the follow-up pressure measurements: The patient coughs and the sensor responds by showing a pressure change.

AcryMed found success with a similar strategy even though it is ultimately AcryMed’s customers who must file for FDA approval rather than AcryMed itself. The company’s SilvaGard coating is intended to prevent the buildup of films on medical devices. Such “biofilms,” said Bill Gibbins, AcryMed founder and chief technology officer, can provide bacteria with a safe haven from which to launch repeated infections against their hosts.

“It turns out organisms are more coordinated (than we thought),” Gibbins said. “They will turn on a gene that makes them sticky and form a tightly adhering colony on a surface. …When a critical mass forms, it will release a chemical signal to make a polysaccharide coating that blankets the organisms.”

If you can keep bacteria-protecting biofilms from forming on devices, said Gibbins, you can keep many infections from forming, too. The company’s SilvaGard, a silver nanoparticle technology, is designed to do just that.

The surfaces of implanted medical devices are perfect for the formation of biofilms, Gibbins said, and the longer they are implanted, the likelier they are to create infection-related problems. “If a Foley (bladder) catheter is implanted three to five days, there is less than a 5 percent chance of an infection,” he said. But after that, he said, the infection rates begin to rise precipitously.

Since he knew his licensees would need FDA approval, Gibbins made sure his company was also working closely with the agency from the start. Concerted efforts included developing specifications for using devices, making sure their materials would meet with approval, establishing a baseline for what kind of antimicrobial performance to expect and determining whether there were any known side effects — of which they found none. In December, I-Flow Corp. of Lake Forest, Calif., received FDA clearance for its ON-Q SilverSoaker antimicrobial catheter, the first medical device to use AcryMed’s SilvaGard.

The payback for both CardioMEMS and AcryMed is not just the initial product, but also the momentum of a successful FDA clearance. Stern said CardioMEMS is now transitioning production of its sensors to a large-scale commercial fab, and the company plans to commence clinical trials on a second product within months. Meanwhile, Gibbins said AcryMed has received inquiries from more than a dozen new potential customers.

Feb. 13, 2006 – BioForce Nanosciences, Inc. is collaborating with Iowa State University (ISU) to develop a sensitive nanotechnology based method for detecting food-borne pathogens. Funding for this project was awarded last week from the University as a part of the “Grow Iowa Values Fund” program which fosters the development of commercial applications from research.

The focus of the research is to provide new tools for the rapid and label-free detection of pathogen specific nucleic acid sequences with the potential to benefit the food industry, the medical and environmental diagnostics industries and the biotechnology and biodefense sectors.

The primary investigator on the project is Byron Brehm-Stecher, a faculty member in the department of Food Science and Human Nutrition at ISU. Eric Henderson, Founder and CEO of BioForce Nanosciences, is co-principal investigator, and Saju Nettikadan, Director of the Research and Application Development group at BioForce, will be a key researcher on this project.

NanoBio names new CFO


February 10, 2006

Feb. 10, 2006 — NanoBio Corp., an Ann Arbor, Mich., biopharmaceutical company developing and commercializing therapies based on proprietary nanoemulsion technology, announced the appointment of David Peralta to the position of vice president and chief financial officer.

Peralta most recently served as vice president and chief financial officer for Arbortext Inc., a venture-backed enterprise software company. While at Arbortext, Peralta played a key role in transforming the company to a fast-growing software business, which ultimately led to Arbortext being acquired in 2005.

Before joining Arbortext, Peralta served for six years as the chief financial officer of Mechanical Dynamics, Inc., a publicly-held engineering software company. Peralta directed all finance and investor relations activities at Mechanical Dynamics during the company’s initial public offering in 1996, and up through the sale of the company in 2002.

Feb. 9, 2006 — Tegal Corp. (Nasdaq: TGAL) announced that a leading wireless component supplier has placed a multiple system order for 901ACS diode plasma etch systems.

The three new systems, valued at over $1 million, will expand the supplier’s existing production capacity in gallium arsenide semiconductors, which are widely used in wireless communications products, according to Tegal. The last multiple system order from this customer occurred in July 2004.

Tegal’s 900ACS series is intended for a wide variety of applications, including pad, zero layer, non-selective nitride, backside and planarization, as well as oxide, nitride, poly and compound materials applications.